Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits

Natural inorganic/organic nanohybrids are a fascinating model in biomaterials design due to their ultra-microstructure and extraordinary properties. Here, we report unique-structured through self-assembly of biomedical nanounits, composed bioactive inorganic nanoparticle core (hydroxyapatite, glass, or mesoporous silica) chitosan shell - namely [email protected] The thin-shelled with could constitute as high 90%, strikingly contrasted the conventional composites. were highly resilient under cyclic load resisted external stress almost an order magnitude effectively than nanohybrids, nano-roughened surface topography, accelerate cellular responses stimulated integrin-mediated focal adhesions. also able multiple therapeutic molecules compartment then release sequentially, demonstrating controlled delivery systems. compartmentally-loaded (dexamethasone, fibroblast growth factor 2, phenamil) shown stimulate anti-inflammatory, pro-angiogenic osteogenic events relevant cells. When implanted vivo calvarium defect 3D-printed scaffold forms, proven new bone formation. Overall, self-assembled from unique properties (ultrahigh content, nano-topography, resilience, multiple-therapeutics delivery, activation), can be considered promising 3D tissue regenerative platforms.